- My Way ~ Frank Sinatra [Listen Here] Plays while Lex takes out the Kasnian army!
- Kickstart My Heart ~ Mötley Crüe [Listen Here] Plays when Lex and Supergirl are battling, James and Ben are fighting, and Alex kicking all the butts of the Children of Liberty.
- St Louis Elegy ~ Mark Lanegan Band [Listen Here] This is the song in the background while the Monitor is doing all his work on Earth 38.
- The First Single (You Know Me) ~ The Format [Listen Here] Plays when young Kara and Alex are walking listening to new music on their shared iPod. Kara is begging Alex not to go to college so she doesn't lose her.
- No Songs Featured
- American Woman ~ Lenny Kravitz [Listen Here] Plays in the Alien Bar when Dreamer kicks the crap out of the Agents of Liberty.
- No Songs Featured
- No Songs Featured
- My Way ~ Frank Sinatra [Listen Here] Plays while Lex takes out his judge and jury!
- Spartacus and Phrygia ~ St. Petersburg Philharmonic Orchestra [Listen Here] Plays when Red Daughter is out seeing nature for the first time.
- Jazz Suite No. 2: VI. Waltz 2 ~ Shostakovich [Listen Here] Red Daughter is reading books that Lex sent.
- Revolutionary ~ Robert Delong [Listen Here] Lex and "Linda Lee" visit National City for the first time.
- No Songs Featured
- Stuck in the Middle With You ~ Stealers Wheel [Listen Here] Plays for the Elite during the opening of the episode!
- Mad World ~ Gary Jules [Listen Here] plays as the March battle falls apart but aliens and humans start helping each other out.
- Hurricane ~ MS MR [Listen Here] Plays while Alex and Kara recap the day on the couch at the end of the episode!
- God Save the Queen ~ The Sex Pistols [Listen Here] Plays when Manchester is addressing the cameras in London.
- Nothing Breaks Like a Heart ~ Mark Ronson [Listen Here] Plays during Nia's party.
- Wild Kids ~ Christen O [Listen Here] Also plays during Nia's party.
- Bad Descision ~ Chromeo [Listen Here] Brainy analyzes the DNA in the closet.
- Kamikaze ~ Walk the Moon [Listen Here] Plays while Kara drives to Nia's home town.
- Light On ~ Maggie Rogers [Listen Here] Nia and Kara arrive at Nia's home.
- On the Floor ~ Electrolightz [Listen Here] Brainy takes on his Frat Boy persona.
- Flames ~ David Guetta & Sia [Listen Here] This is the song when Lena and Kara are working out at the gym together.
- Really Gone ~ CHVRCHES [Listen Here] This is the big wrap up song played at the end of the episode!
- Save Me ~ Remy Zero [Listen Here] Plays when we arrive in Smallville!
- Killing Machine ~ Tony Crown [Listen Here] Plays at the end of the episode when Ben Lockwood is being taken to prison and Supergirl flies above watching.
- Grace ~ Rose Cousins [Listen Here] Plays at the end of the episode when James speaks with Lena
- What Lovers Do ~ Maroon 5 [Listen Here] Plays when Eliza tells Alex canned cranberries aren't as good.
- Just Tell Me ~ Nico Yaryan [Listen Here] Plays as the group at Thanksgiving discusses humans with powers and James' infiltration of the Children of Liberty.
- St Louis Elegy ~ Mark Lanegan Band [Listen Here] Plays at the end of the episode.
- On My One ~ Jake Bugg [Listen Here] Song featured at the end of the episode with Manchester Black setting up in National City
- Hero Sometimes ~ Nine One One [Listen Here] Song featured in the episode 404 trailer.
- Trouble ~ Derek Pitts and the Bullets [Listen Here] Plays when J'onn visits the alien bar to discuss how people feel about the President stepping down.
- A Little Honey ~ Nathaniel Rateliff & The Night Sweats [Listen Here] Plays when Brainy and Nia are at the Pizza Place.
- Trickster Blues ~ RF Shannon [Listen here] Plays at the alien bar when Kara apologizes to J'onn near the end of the episode.